1 BrainXcan results

In this analysis, we tested 327 structural and diffusion MRI-derived phenotypes with cross validated spearman correlation >= 0.101.

For the main analysis we focused on 261 IDPs, which include 48 cortical volumes, 10 sub-cortical volumes, 13 sub-cortical gray matter volumes. In below, we show the overall number of IDP by IDP subtype in the main results.

subtype n
Brainstem 1
FA 46
Gray-Brainstem 1
Gray-Cerebellum 27
Gray-Cortical 48
Gray-Subcortical 13
ICVF 44
ISOVF 13
OD 45
PC-Cerebellum-1 1
PC-Cortical-1 1
PC-FA-TBSS-1 1
PC-ICVF-TBSS-1 1
PC-ISOVF-TBSS-1 1
PC-OD-TBSS-1 1
PC-Subcortical_GMvol-1 1
PC-Subcortical_vol-1 1
Subcortical 10
Total 5

The p-value being used is .

Among 261 IDPs (109 T1 and 152 diffusion MRI, including the subtype-specific PCs), 3 were significantly associated with SCZ (FDR < \(0.1\)).

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The top 5 associations for dMRI are

IDP subtype region side zscore fdr IDP -> Phenotype Phenotype -> IDP link
PC-ICVF-TBSS-1 PC-ICVF-TBSS-1 PC-ICVF-TBSS-1 NA -3.446 0.07428 0.04265 0.01448 MR plot
PC-FA-TBSS-1 PC-FA-TBSS-1 PC-FA-TBSS-1 NA -3.274 0.0921 0.4953 0.02081 MR plot

The top 5 associations for T1 are

IDP subtype region side zscore fdr IDP -> Phenotype Phenotype -> IDP link
IDP-25020 Subcortical hippocampus right 4.233 0.00603 0.525 0.5756 MR plot

2 Visualization of associations in the brain

2.1 T1

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2.2 dMRI

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3 BrainXcan MR Figures

3.1 PC-FA-TBSS-1

PC-FA-TBSS-1

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3.2 PC-ICVF-TBSS-1

PC-ICVF-TBSS-1

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3.3 IDP-25020

Volume of right hippocampus (from T1 brain image)

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